Abstract
Objectives
Despite the advantages of prostate-specific membrane antigen (PSMA)-PET/MR over PSMA-PET/CT, its relatively long scanning time and suboptimal PET attenuation correction necessitate careful assessment of the most appropriate setting for this type of study. We assessed lesion agreement between PSMA-PET/MR and PSMA-PET/CT in patients undergoing initial evaluation of prostate cancer.
Methods
This was a prospective study of consecutive patients with histological biopsy-proven prostate cancer who underwent pelvic PSMA-PET/MR followed by whole-body PSMA-PET/CT. All conspicuous PSMA-avid foci were counted on PSMA-PET/CT and PSMA-PET/MR with CT or MR correlation. Analysis was performed for intra-prostatic lesions, capsular invasion, seminal vesicle involvement and lymph node and bone involvement. Incidental and significant findings seen on PSMA-PET/CT outside the PSMA-PET/MR field of view were also analysed. Agreements between PSMA-PET/CT and PSMA-PET/MR findings were performed using Cohen’s kappa test.
Results
Image analysis was performed on 140 patients (mean age, 67.3 ± 8.2 years). Agreement between PSMA PET/CT and PSMA-PET/MR was very good for intra-prostatic PSMA-avid foci (K = 0.85) and pelvic lymph nodes (K = 0.98), good for PSMA-avid bone metastases (K = 0.76) and fair for prostatic capsular invasion (K = 0.25) and seminal vesicle involvement (K = 0.31). Twelve patients (8.5%) had incidental findings and two patients (1.4%) had clinically significant findings.
Conclusion
Limited pelvic PSMA-PET/MR has very good agreement with PET/CT regarding PSMA-avid prostatic, regional lymph nodes and bone lesions, and is superior to PET/CT with regard to capsular invasion and seminal vesicle involvement.
Key Points
• Limited pelvic PSMA-PET/MR is superior to whole-body PSMA-PET/CT in detecting extensions of localised disease, mainly due to the high soft tissue resolution of MR.
• Limited pelvic PSMA-PET/MR may be useful for initial evaluation of histological biopsy-proven prostate cancer.
• Further studies are warranted to evaluate limited pelvic PSMA-PET/MR for screening and active surveillance in selected populations.
Similar content being viewed by others
Abbreviations
- 18F:
-
18-Fluorine
- 68Ga:
-
68-Gallium
- CI:
-
Confidence interval
- CT:
-
Computed tomography
- FOV:
-
Field of view
- GS:
-
Gleason score
- mp-MRI:
-
Multi-parametric magnetic resonance imaging
- MR:
-
Magnetic resonance
- OSEM:
-
Ordered subset expectation maximisation
- PET:
-
Positron emission tomography
- PI-RADS:
-
Prostate Imaging-Reporting and Data System
- PSMA:
-
Prostate-specific membrane antigen
- SE:
-
Standard error
References
Rauscher I, Maurer T, Beer AJ et al (2016) Value of 68Ga-PSMA HBED-CC PET for the assessment of lymph node metastases in prostate cancer patients with biochemical recurrence: comparison with histopathology after salvage lymphadenectomy. J Nucl Med 57(11):1713–1719
Eiber M, Maurer T, Souvatzoglou M et al (2015) Evaluation of hybrid (6)(8)Ga-PSMA ligand PET/CT in 248 patients with biochemical recurrence after radical prostatectomy. J Nucl Med 56(5):668–674
Schwarzenboeck SM, Rauscher I, Bluemel C et al (2017) PSMA ligands for PET imaging of prostate cancer. J Nucl Med 58(10):1545–1552
Maurer T, Gschwend JE, Rauscher I et al (2016) Diagnostic efficacy of (68)gallium-PSMA positron emission tomography compared to conventional imaging for lymph node staging of 130 consecutive patients with intermediate to high risk prostate cancer. J Urol 195(5):1436–1443
Pyka T, Okamoto S, Dahlbender M et al (2016) Comparison of bone scintigraphy and (68)Ga-PSMA PET for skeletal staging in prostate cancer. Eur J Nucl Med Mol Imaging 43(12):2114–2121
Giesel FL, Sterzing F, Schlemmer HP et al (2016) Intra-individual comparison of (68)Ga-PSMA-11-PET/CT and multi-parametric MR for imaging of primary prostate cancer. Eur J Nucl Med Mol Imaging 43(8):1400–1406
Berger I, Annabattula C, Lewis J et al (2018) (68)Ga-PSMA PET/CT vs. mpMRI for locoregional prostate cancer staging: correlation with final histopathology. Prostate Cancer Prostatic Dis 21(2):204–211
Park SY, Zacharias C, Harrison C et al (2018) Gallium 68 PSMA-11 PET/mr imaging in patients with intermediate- or high-risk prostate cancer. Radiology. 288(2):495–505
Eiber M, Weirich G, Holzapfel K et al (2016) Simultaneous 68Ga-PSMA HBED-CC PET/MRI improves the localization of primary prostate cancer. Eur Urol 70(5):829–836
Al-Bayati M, Grueneisen J, Lütje S et al (2018) Integrated 68gallium labelled prostate-specific membrane antigen-11 positron emission tomography/magnetic resonance imaging enhances discriminatory power of multi-parametric prostate magnetic resonance imaging. Urol Int 100(2):164–171
Domachevsky L, Goldberg N, Bernstine H, Nidam M, Groshar D (2018) Quantitative characterisation of clinically significant intra-prostatic cancer by prostate-specific membrane antigen (PSMA) expression and cell density on PSMA-11. Eur Radiol 28(12):5275–5283
Öbek C, Doğanca T, Demirci E et al (2017) The accuracy of (68)Ga-PSMA PET/CT in primary lymph node staging in high-risk prostate cancer. Eur J Nucl Med Mol Imaging 44(11):1806–1812
Freitag MT, Radtke JP, Hadaschik BA et al (2016) Comparison of hybrid (68)Ga-PSMA PET/MRI and (68)Ga-PSMA PET/CT in the evaluation of lymph node and bone metastases of prostate cancer. Eur J Nucl Med Mol Imaging 43(1):70–83
Domachevsky L, Bernstine H, Goldberg N et al (2017) Early (68)GA-PSMA PET/MRI acquisition: assessment of lesion detectability and PET metrics in patients with prostate cancer undergoing same-day late PET/CT. Clin Radiol 72(11):944–950
Thalgott M, Düwel C, Rauscher I et al (2018) One-stop shop whole-body (68)Ga-PSMA-11 PET/MRI compared to clinical nomograms for preoperative T- and N-staging of high-risk prostate cancer. J Nucl Med 59(12):1850–1856
Verburg FA, Pfestroff A (2016) Imaging: PSMA PET-CT in initial prostate cancer staging. Nat Rev Urol 13(9):498–499
Zhang Q, Zang S, Zhang C et al (2017) Comparison of (68)Ga-PSMA-11 PET-CT with mpMRI for preoperative lymph node staging in patients with intermediate to high-risk prostate cancer. J Transl Med 15(1):230
Afshar-Oromieh A, Haberkorn U, Schlemmer HP et al (2014) Comparison of PET/CT and PET/MRI hybrid systems using a 68Ga-labelled PSMA ligand for the diagnosis of recurrent prostate cancer: initial experience. Eur J Nucl Med Mol Imaging 41(5):887–897
Kabasakal L, Demirci E, Ocak M et al (2015) Evaluation of PSMA PET/CT imaging using a 68Ga-HBED-CC ligand in patients with prostate cancer and the value of early pelvic imaging. Nucl Med Commun 36(6):582–587
Perveen G, Arora G, Damle NA et al (2018) Role of early dynamic positron emission tomography/computed tomography with 68Ga-prostate-specific membrane antigen-HBED-CC in patients with adenocarcinoma prostate: initial results. Indian J Nucl Med 33(2):112–117
Uprimny C, Kroiss AS, Decristoforo C et al (2017) Early dynamic imaging in (68)Ga- PSMA-11 PET/CT allows discrimination of urinary bladder activity and prostate cancer lesions. Eur J Nucl Med Mol Imaging 44(5):765–775
Hofman MS, Iravani A, Nzenza T, Murphy DG (2018) Advances in urologic imaging: prostate-specific membrane antigen ligand PET imaging. Urol Clin North Am 45(3):503–524
Fendler WP, Schmidt DF, Wenter V et al (2016) 68Ga-PSMA PET/CT detects the location and extent of primary prostate cancer. J Nucl Med 57(11):1720–1725
Muehlematter UJ, Rupp NJ, Mueller J, Eberli D, Burger IA (2018) 68Ga-PSMA PET/MR-positive, histopathology-proven prostate cancer in a patient with negative multiparametric prostate MRI. Clin Nucl Med 43(8):e282–e2e4
Beheshti M, Paymani Z, Brilhante J et al (2018) Optimal time-point for (68)Ga-PSMA-11 PET/CT imaging in assessment of prostate cancer: feasibility of sterile cold-kit tracer preparation? Eur J Nucl Med Mol Imaging 45(7):1188–1196
Acknowledgements
The authors acknowledge Zohar Nitsan, Inbal Machcat and Hagai Baruch for their excellent work in patient scanning, Dr. Limor Shaharabani-Gargir for patient management and Dr. Sharon Furman-Assaf for editing.
Funding
The authors state that this work has not received any funding.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Guarantor
The scientific guarantor of this publication is Prof. David Groshar.
Conflict of interest
The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
Statistics and biometry
One of the authors (Meital Nidam) has significant statistical expertise.
Informed consent
Written informed consent was obtained from all subjects (patients) in this study.
Ethical approval
Institutional Review Board approval was obtained.
Methodology
• Retrospective
• Diagnostic or prognostic study
• Performed at one institution
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Domachevsky, L., Bernstine, H., Goldberg, N. et al. Comparison between pelvic PSMA-PET/MR and whole-body PSMA-PET/CT for the initial evaluation of prostate cancer: a proof of concept study. Eur Radiol 30, 328–336 (2020). https://doi.org/10.1007/s00330-019-06353-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00330-019-06353-y