Multiparametric MRI improves assessment of treatment response in glioblastoma

Evaluation of treatment response is a challenging issue in glioblastoma. There are several traps when making the decision between pseudoprogression and true progression. This systematic review and meta-analysis show that Multiparametric MRI provides important additional clues.

Key points:

• Multiparametric MRI shows high diagnostic performance for early treatment response in glioblastoma.
• Multiparametric MRI could differentiate true progression from pseudoprogression in newly diagnosed glioblastoma.
• The normalized rCBV derived from DSC was the most commonly used parameter.

Article:  Multiparametric MRI as a potential surrogate endpoint for decision-making in early treatment response following concurrent chemoradiotherapy in patients with newly diagnosed glioblastoma: a systematic review and meta-analysis

Authors: Chong Hyun Suh, Ho Sung Kim, Seung Chai Jung, Choong Gon Choi and Sang Joon Kim